Breakthrough Publications

     
 
   

A team of scientists from Children's Hospital Boston led by Leslie Silberstein and Cesar Nombela-Arrieta employed quantitative imaging cytometry platform iCys in combination with confocal and multiphoton microscopy to comprehensively map phenotypically defined haematopoietic stem and progenitor (HSPC) subsets.  According to the results of the study published in Nature Cell Biology they demonstrated that hypoxic profile of HSPCs is unrelated to anatomical positioning in defined bone marrow microenvironments and proximity to vascular structures, presenting unequivocal evidence to support an alternative view to the widely accepted notion of super hypoxic HSPC niche in bone marrow .

Nature Cell Biology, 2013

   

A team of researchers led by  Joseph Italiano and Jonathon Thon at Harvard School and Brigham and Women's Hospital, Boston employed LSC technology to develop the first quantitative assay providing insights into the terminal mechanisms of platelet production.  In collaboration with UC Davis mathematicians they developed a model of the forces inside the cells that turn into platelets, accurately predicting their final size and shape.

 



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Publications and Presentations
 

Multi-Media Imaging Cytometry Technology Presentation

     

Methods in Cell Biology


Volume 102: Advances in Instrumentation and Methods

Volume 103: Advances in Applications

     

Cytometry: A Century of Innovation

Multi-Media Presentation with commentary by Dr. Louis Kamentsky